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Zitsel

Inexpensive Indian synonym for Celebrex. Where can I Buy Celecoxib 200 mg, 100 mg Online No Prescription Each tablet contains 200 mg of celecoxib. It is prescribed as symptomatic therapy for back pain, ankylosing spondylitis, signs of rheumatoid arthritis and osteoarthritis. Over-the-counter.

The main contraindications for the capsules Zicel and Celebrex are the same:

 

  • intolerance to celecoxib and sulfonamides;
  • hypersensitivity to NSAIDs and acetylsalicylic acid;
  • pregnancy and lactation;
  • peptic ulcer;
  • renal failure.

 

Like Celebrex, Zicel is taken twice a day at 200 mg. With a weak effect, the dosage is increased to 400 mg.

It is rare in pharmacies, the cost of packaging is about 140 rubles.

Description of Celebrex

The drug acts as a selective inhibitor of cyclooxygenase of the second type (COX-2). Suppresses the synthesis of prostaglandins. According to the chemical structure, the drug belongs to the coxib group.

The composition of the medication includes substances related to selective inhibitors of the synthesis of cyclooxygenases of cytochrome. Thanks to them, the effect of the drug is provided.

The main component is celecoxib in an amount of 100 or 200 mg.

The drug is used to relieve back pain, inflammation, as well as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, primary dysmenorrhea. In addition, the drug has an antipyretic effect..

To date, Celebrex is one of the safest NSAIDs, but because of the expensive price, it is often necessary to use analogues.

The cost of the drug, depending on the dose of the active substance, is in the range of 160–950 rubles.

Analogs

Celecoxib can be replaced with the following medicines:

 

  1. Celebrex is an original medication containing celecoxib as an active substance. The drug is available in 100 mg, 200 mg and 400 mg capsules. It is forbidden to prescribe to persons under 18 years of age, patients in position and breastfeeding.
  2. Dilaxa contains celecoxib as an active ingredient. On sale, the drug is in capsules. They are not used in pediatric practice, for the treatment of pregnant and lactating patients.
  3. Celecoxib-Vial is a domestic medicine, which is a complete analogue of the drug Celecoxib. NSAIDs are available in capsules of 100 and 200 mg, which are contraindicated in children, women who have a baby and support breastfeeding..
  4. Rowoksib-Routek is a complete analogue of the drug Celecoxib. This is a Russian medication that is available in capsules for oral administration. It is forbidden to minors, pregnant and lactating..

 

Replace celecoxib with an analog after consulting a doctor.

The cost of Celecoxib is on average from 1620 to 8050 rubles.

Side effects

The main side effects of non-steroidal anti-inflammatory drugs are associated with the gastrointestinal tract. The drug causes dyspepsia, abdominal pain and diarrhea in 4-9% of patients. Gastrointestinal problems also become a leading cause of treatment discontinuation.

In several studies, the effects of the drug on the mucous membrane of the stomach and duodenum were specifically studied endoscopically. In two 12-week double-blind trials, a total of 2157 patients with arthritis and polyarthritis were treated with placebo, celecoxib, or naproxen. In all patients treated, with initial endoscopy there were no erosive changes. After 12 weeks, the following ulcer indicators were found in different treatment groups: placebo - 2%, celecoxib - 4%, naproxen - 17%.

In another study, patients received celecoxib (2 times 200 mg / day), diclofenac (2 times 75 mg / day), or ibuprofen (3 times 800 mg / day). Endoscopy was performed every 3 weeks for 3 months. The frequency of gastroduodenal ulcers was 7% for celecoxib, less than 10% for diclofenac, and 23% for ibuprofen..

In a long six-month study, diclofenac also showed a significantly higher ulcer frequency than celecoxib. However, the reliability of this result should be clarified, since endoscopy was not performed at the beginning of the study..

In these studies, those patients in the celecoxib group who also took a low dose of acetylsalicylic acid (ASA) had a slightly higher risk of developing ulcers (but not as high as in the comparison groups).

Platelet aggregation did not change in several small studies of celecoxib. An increase in transaminases was noted only slightly more frequently with celecoxib than with placebo. Regarding renal function, there is no evidence to suggest that celecoxib differs from other non-steroidal anti-inflammatory drugs in a positive or negative way. People with aspirin intolerance should not be treated with celecoxib..

Possible contraindications

Instructions for use prohibits the appointment of celecoxib in the following cases:

 

  • asthma attacks
  • anemia
  • coronary artery bypass grafting, if a small amount of time has passed since the operation;
  • accumulation of blood in the lumen of the gastrointestinal tract;
  • allergic reactions to aspirin, NSAIDs and other groups of drugs with a similar principle of action;
  • chronic heart failure;
  • functional disorders in the liver and kidneys in a severe stage;
  • stomach ulcer;
  • circulatory disorders of the brain;
  • inflammatory bowel disease.

 

Celecoxib in any form and form, regardless of what price is indicated on its analogues, is forbidden to take to people with hypersensitivity to at least one of the components of the drug.